Introduction
Film coating was developed as undercoating for sugar coating in the 1950’s and film coated tablets were eventually introduced early in the 1970’s, Since then, much development work aimed at increasing the production rate of film-coated tablets and reducing the cost has been done in order to improve the efficiency of pharmaceutical manufacturing, as well as the bioavailability of drugs, and film coating is now a well established and effective technique.
HYDROCEL is the brand name of Hydroxypropyl Methylcellulose. It has been subject of a continuous program of development quality improvement. Gastro soluble coatings, cellulose, veg capsules of this type are now in wide spread use throughout the world. Although drug properties are the key factor in medicinal formulations, the physical from or the finish of a preparation is also nimportant. HYDROCEL is easy to use as a film-coating material and gives an excellent finish. It is versatile, and is suitable for many applications in the design of film-coated tablet as well as veg capsule formulations.
In addition, HYDROCEL is effective as a binder, since it does not interact with drugs, and has superior stability, nonionic, character, etc. HYDROCEL is widely used as a binder for granulation, and is available in various viscosity grades for granulation purposes.
HYDROCEL can make a valuable contribution in various areas of pharmaceutical technology. Detailed technical information is available upon request.
Designation & Chemical Structure HYDROCEL
Designation: Hydroxypropyl Methylcellulose Substitution Type 2910 (USP)
Chemical Name: Hydroxypropyl Methylcellulose
Generic Name: HPMC
References: USP / Ph.Eur /BP/ JP/
Specifications
HYDROCEL meets all the requirements of USP Hydroxy Propyl Methyl Cellulose (Substitution Type 2910). Moreover, carries out test for foreign matter contamination, Microbiological contamination, yellowness index, etc. in addition to the test prescribed in the mentioned pharmacopeias to ensure direct control of the quality HYDROCEL is manufactured in accordance with the FDA’s, good manufacturing practices. A certificate of analysis HYDROCEL is routinely attached to the product, and incorporates. The test results concerning the following quality specifications, except for the case where the USP/Ph.Eur/BP/JP/ IP specifications are acceptable to the customer or where special specifications are requested.
Viscometric properties
A. Viscosity between concentration and viscosity of HYDROCEL AW 3,5 and 15 in water at 20 °C and 40 °C in Fig. 2. The type of product and the concentration used should be selected depending on the required usage. For film coating concentration reaching 80-100 cps are optimum. For use as a binder, a low viscosity grades are effective.
B. Viscosity of organic solvent solutions HYDROCEL is soluble in aqueous alcohols such as Ethanol and Isopropanol containing in a ratio of more than 1:1 but insoluble in simple alcohols. Organic solutions can be prepared in mixtures of methylene chloride and alcohol. There are various disadvantages to the use of Organic Solvents in pharmaceutical processing, but if they require to be use, we recommended Methylene Chloride – ethanol and water- ethanol mixtures as Solvents.